Evaluation of serum and ascitic fluid proteomes in dogs with dilated cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F16%3A43874105" target="_blank" >RIV/62157124:16170/16:43874105 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.9775/kvfd.2015.14429" target="_blank" >http://dx.doi.org/10.9775/kvfd.2015.14429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.9775/kvfd.2015.14429" target="_blank" >10.9775/kvfd.2015.14429</a>

Result language

angličtina

Original language name

Evaluation of serum and ascitic fluid proteomes in dogs with dilated cardiomyopathy

Original language description

The aim of the study was to investigate serum global proteomes in dogs with overt dilated cardiomyopathy (DCM) and to evaluate protein expression in serum with that in ascitic fluid. Eight healthy dogs (control group) and 8 dogs with DCM were included in the study. DCM was diagnosed based on echocardiographic evidence including increased left ventricular dimension at diastole and systole, increased E point to septal separation, and decreased fractional shortening. Serum and ascitic fluid samples were analyzed for proteomes using a label-free LC-MS/MS method. Proteome analyses revealed significantly different expressions of eight proteins in all samples. Expressions in serum of apolipoprotein (Apo) A1, Ig heavy chain V, superoxide dismutase and plasminogen were higher (P<0.001), while expressions of clusterin, hemoglobin subunit ß, Apo-CII, and ? 2 glycoprotein I (ß2GPI) were lower (p<0.001) in dogs with DCM than in control dogs. In addition, Apo-A1, clusterin, hemoglobin subunit ß, Ig heavy chain V, plasminogen and ß2GPI were down-regulated whereas Apo-CII and superoxide dismutase were up-regulated in ascitic fluid compared with serum in dogs with DCM. Data obtained in the present study suggest that serum and/or ascitic fluid proteomes may explain some of the pathophysiological mechanisms involved in the progression of DCM Dilate Kardiyomiyopatili Köpeklerde Serum ve Asites S?v?s? Proteomlar?n?n Araşt?r?lmas?. Available from: https://www.researchgate.net/publication/283789562_Dilate_Kardiyomiyopatili_Kopeklerde_Serum_ve_Asites_Sivisi_Proteomlarinin_Arastirilmasi [accessed Jan 8, 2016].

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kafkas Universitesi Veteriner Fakultesi Dergisi

ISSN

1300-6045

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

2

Country of publishing house

TR - TURKEY

Number of pages

7

Pages from-to

273-279

UT code for WoS article

000374311900017

EID of the result in the Scopus database

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