Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F17%3A43875575" target="_blank" >RIV/62157124:16170/17:43875575 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00095956 RIV/62157124:16370/17:43875575

Result on the web

<a href="http://dx.doi.org/10.2174/1567201813666160502142856" target="_blank" >http://dx.doi.org/10.2174/1567201813666160502142856</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1567201813666160502142856" target="_blank" >10.2174/1567201813666160502142856</a>

Result language

angličtina

Original language name

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Original language description

Background: Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions. Furthermore, there has been a noticeable increase in microorganisms resistant to these preparations. Mucoadhesive buccal films represent a modern therapeutic system for the treatment of oral mucosal fungal infection paired with a high degree of patient compliance. Ciclopirox olamine applied directly onto the oral mucosa offers an attractive alternative to treatment with systemic antifungals thanks to its low incidence of resistance and side effects. Objective: The aim of this work was to evaluate the pharmacokinetic parameters of ciclopirox olamine after the buccal application of mucoadhesive film prepared by the solvent casting method. Method: A chromatographic method using an internal standard was developed and validated for evaluation of ciclopirox olamine plasma concentrations. Method accuracy was 88.5-104.6% and 89.5-99.7% for interday and intraday assays, respectively. Results: The pharmacokinetic properties of ciclopirox olamine were studied in New Zealand White rabbits. The mucoadhesive films containing ciclopirox olamine in a total dose of 34.4 (33.0; 35.9) mg/kg were applied to all the rabbits. Plasma ciclopirox olamine concentrations were determined during the 12 h following application. The time taken to reach maximum plasma concentration was 1.7 (1.1; 2.2) h after the drug administration with cmax 5.73 (4.18; 7.28) ?g/ml. Overall elimination half-life was 3.8 (1.9; 10.8) h. Conclusion: The experiment suggests that oral mucoadhesive film may be a valuable alternative ciclopirox olamine administration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/NT14477" target="_blank" >NT14477: Modern Dosage Form for the Therapy of Oral Candidoses</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Drug Delivery

ISSN

1567-2018

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

1

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

10

Pages from-to

99-108

UT code for WoS article

000399783000011

EID of the result in the Scopus database

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