Newborn foal with atypical myopathy.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F18%3A43876643" target="_blank" >RIV/62157124:16170/18:43876643 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/jvim.15236" target="_blank" >http://dx.doi.org/10.1111/jvim.15236</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jvim.15236" target="_blank" >10.1111/jvim.15236</a>

Result language
angličtina
Original language name
Newborn foal with atypical myopathy.
Original language description
The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal?s dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal?s blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare?s placenta with consequent transfer to fetus or (b) these compounds were secreted into mare?s milk.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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