Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877294" target="_blank" >RIV/62157124:16170/19:43877294 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/19:N0000001

Result on the web

<a href="https://doi.org/10.1007/s13353-018-0471-4" target="_blank" >https://doi.org/10.1007/s13353-018-0471-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13353-018-0471-4" target="_blank" >10.1007/s13353-018-0471-4</a>

Result language

angličtina

Original language name

Structural and copy number chromosome abnormalities in canine cutaneous mast cell tumours

Original language description

Mast cell tumours (MCTs) are the most common skin tumours in dogs. Their clinical behaviour is variable and their aetiology remains largely unknown. We performed a metaphase fluorescence in situ hybridisation (FISH) with whole chromosome painting probes, and interphase FISH with BAC probes for 14 cancer-related genes to reveal clonal structural chromosome rearrangements and copy number variants (CNVs) in canine cutaneous MCTs. The metaphase FISH performed in three MCTs revealed several clonal monosomies and trisomies and two different chromosome rearrangements. No centric fusions were detected. The interphase FISH showed a variety of low frequency CNVs for the individual cancer-related genes. The heterogeneous character of the detected abnormalities indicates increased chromosome instability in canine MCTs. The clonal gain of chromosome 11 was detected in 81% (13/16) of the MCTs. Further research is needed to evaluate the significance of this abnormality as prognostic factor for the survival time or recurrence risk assessments in canine cutaneous MCTs.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40301 - Veterinary science

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of applied genetics

ISSN

1234-1983

e-ISSN

—

Volume of the periodical

60

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

63-70

UT code for WoS article

000458251100008

EID of the result in the Scopus database

2-s2.0-85054570246