The borrelial myocarditis in dog - 1st case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877505" target="_blank" >RIV/62157124:16170/19:43877505 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The borrelial myocarditis in dog - 1st case report
Original language description
Borreliosis is a well-known condition that can induce several clinical syndromes in human beings and animals leading to several complications even death. The less common myocardial form of the disease can lead to arrhythmia and myocardial inflammation; those changes may induce cardiomyopathy, which is a serious manifestation of the disease though rare. This presentation describes a case of an 8-year-old female Labrador retriever that was admitted due to progressive movement complications (reluctance to move, fatigue), neuromuscular signs (generalized body weakness, decreased flexor reflexes, dysphonia) and polypnea and irregular heart rhythm. The female was often infested by ticks. During hospitalization the patient developed different types of arrhythmias (supraventricular tachycardia, several degrees of atrioventricular blocks and ventricular bigeminism) that did not respond well to therapy (infusion therapy, doxycycline, antiarrhythmics, furosemide). There was seropositivity to Borrelia sp. (positive Borrelia-C6 SNAP 4Dx Plus test and borrelia indirect fluorescent antibody IgM and IgG tests confirmed with Western blott with positive VlsE and OpsC bands). Negative ELISA IgG OspA confirmed that animal was not vaccinated against Borrelia sp. Serum was also positive for Toxoplasma gondii IgM and IgG antibodies. Increased cardiac troponins and NT-proBNP showed severe myocardial damage and ongoing cardiac failure. The dog subsequently died as a result of heart disease and arrest after ventricular fibrillation. Pathology demonstrated myocarditis. Real-time PCR of myocardium confirmed positivity to borreliosis. Positive sample was sequenced as B. burgdorferi sensu stricto. DNA T. gondii was not detected in heart tissue samples by real-time PCR. The correlation of serology, cardiac markers, clinical course, pathology concluded a Lyme myocarditis. The myocardial damage caused by T. gondii was excluded negative PCR. To the authors? knowledge this would be the first confirmed case of borreliosis inducing myocarditis and sudden death in a dog.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů