Occurrence vector-borne pathogens in canine nodal lymphomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877554" target="_blank" >RIV/62157124:16170/19:43877554 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Occurrence vector-borne pathogens in canine nodal lymphomas

Original language description

Lymphoma is one of the most common malignancies in dogs, but little is known about a possible infectious etiology of this cancer. In humans, the detection of vector-borne pathogen DNA in non-Hodgkin lymphomas (NHL) has raised the hypothesis that these infections are causally related to NHL development in people. Several veterinary reports have suggested a possible link between some vector-borne diseases and the tumorigenesis of canine NHL. The aim of our prospective study was to assess the DNA presence of vector-borne diseases in canine nodal lymphoma classified according to WHO classification. We conducted a pilot study including 36 non-treated dogs with nodal lymphoma distributed within 11 WHO subtypes. History of tick infestation and possible vector-borne infection was ascertained through structured owner´s interviews. Real-time PCR analyses for Anaplasma platys and phagocytophilum, Babesia canis, Borrelia burgdorferi spp., Ehrlichia canis, Hepatozoon canis, Leishmania infantum and Candidatus Neoehrlichia mikurensis were performed from peripheral blood in all patients and from lymph node tissue in 13 dogs. Twenty-one dogs had a tick infestation in the last three months and five dogs had a vector-borne infection in their history (three Anaplasma phagocytophilum, two Babesia canis). Vector-borne pathogen DNA was not detected in any peripheral blood and/or lymph node of lymphoma patients by real-time PCR. Our pilot study found no evidence that vector-borne pathogens are directly involved in common types of canine nodal lymphoma. Future studies including larger number of patients and detecting DNA of vector-borne agents in other tumor tissues (bone marrow, liver, spleen) are scheduled/in progress.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů