Novel functions of caspase-9 in endochondral bone development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877597" target="_blank" >RIV/62157124:16170/19:43877597 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Novel functions of caspase-9 in endochondral bone development
Original language description
Caspase-9, as an initiator of the mitochondrial apoptotic pathway, triggers cell death by activation of the effector caspases -3, -6 and -7. Currently, the action of caspases has been re-evaluated because of their nonapoptotic roles in many systems. We have previously shown non-apoptotic activation of pro-apoptotic caspases during bone development. Here we have focused on caspase-9, which becomes activated in nonapoptotic chondrocytes of the growth plate of endochondral (long) bones.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů