Biological active compounds from Morus alba root bark
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877665" target="_blank" >RIV/62157124:16170/19:43877665 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/19:43877665
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Biological active compounds from Morus alba root bark
Original language description
In vitro biological screening of 26 mulberry constituents identified promising candidate drugs for further biological research. Antiviral, antibacterial, anti-inflammatory, and antiplasmodial activities were evaluated. Five prenylated compounds, together with a phenolic ester, proved to possess inhibitory activity against the replication of HSV-1 or HSV-2 with IC50 (EC50) values of 0.64?1.93 ?g/mL. Molecular docking studies for HSV were performed for active compounds. Several compounds exhibited significant growth inhibition of all bacterial strains tested with MICs values 1?16 ?g/mL. Furthermore, one compound was found to inhibit COX-2 with a greater activity than positive control indomethacin.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů