Leukocyte ratios as prognostic indicators in canine peripheral T-cell lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43878122" target="_blank" >RIV/62157124:16170/19:43878122 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Leukocyte ratios as prognostic indicators in canine peripheral T-cell lymphoma

Original language description

Peripheral T-cell lymphoma (PTCL) encompasses a group of aggressive lymphomas. In humans, leukocyte ratios are helpful in refining the cancer prognosis. However, for PTCL, the association of neutrophil-to-lymphocyte ratio (NLR) with inferior survival was only recently identified. No study was focused on leukocyte ratios in canine PTCL. The aim of this retrospective analysis was to evaluate NLR, neutrophil-to-eosinophil (NER), neutrophil-to-monocyte (NMR), lymphocyte-to-monocyte (LMR), eosinophil-to-monocyte (EMR) and eosinophil-to-lymphocyte (ELR) ratios as prognostic factors in canine PTCL. A total of 21 nontreated patients with pretreatment blood analysis were included. All patients were treated by chemotherapy (CHOP or LOPP). Cut-off values 3.5 for NLR, 25.0 for NER and 1.2 for LMR were set as previously published in canine lymphoma and mast cell tumour. Cut-off values 8.0 for NMR, 0.1 for EMR and 0.11 for ELR were previously reported in human studies. All ratios were independent from age, weight, sex, lymphoma grade, stage or substage. Initial treatment response was negatively linked to high NER (p=0.002) and low ELR (p=0.03). No differences in progression-free survival (PFS) nor lymphoma-specific survival (LSS) were observed in NLR, LMR, EMR or NMR. High NER was associated with inferior PFS (43 vs. 152 days, p=0.004) and LSS (94 vs. 210 days, p=0.03). Low ELR was linked to shorter PFS (33 vs. 144 days, p=0.003) and LSS (68 vs. 205 days, p=0.004). In our group of PTCL patients only NER and ELR indicated inferior survival. However larger prospective studies on different WHO lymphoma types with standardized treatment protocol are warranted.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů