Ex-vivo hodnocení cytotoxicity alginátových částic jako nosiče pro přívod léčiva do kolonu

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43878204" target="_blank" >RIV/62157124:16170/19:43878204 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/19:43878205 RIV/62157124:16370/19:43878204 RIV/62157124:16370/19:43878205 RIV/62157124:16810/19:43878204
Result on the web
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DOI - Digital Object Identifier
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Result language
čeština
Original language name
Ex-vivo evaluation of cytotoxicity of alginate matrices as a carrier for colon delivery systém
Original language description
Alginate as a polymer specifically biodegradable by colonic bacterial enzymes was used for the preparation of basic matrix for colon targeting. The external ionic gelation was used as a method of preparation and Ca2+, Zn2+ and their mixture were used as cross-linking ions. The safety of internal administration of prepared samples has been determined by the ex-vivo cytotoxicity evaluation. A slight decrease of the TC50 was achieved after treatment using the ion mixture.
Czech name
Ex-vivo evaluation of cytotoxicity of alginate matrices as a carrier for colon delivery systém
Czech description
Alginate as a polymer specifically biodegradable by colonic bacterial enzymes was used for the preparation of basic matrix for colon targeting. The external ionic gelation was used as a method of preparation and Ca2+, Zn2+ and their mixture were used as cross-linking ions. The safety of internal administration of prepared samples has been determined by the ex-vivo cytotoxicity evaluation. A slight decrease of the TC50 was achieved after treatment using the ion mixture.

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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