Influence of fentanyl, ketamine, and lidocaine on tear production in healthy conscious dogs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F22%3A43879215" target="_blank" >RIV/62157124:16170/22:43879215 - isvavai.cz</a>
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S1938973621001057?token=9A527BC5108B866755BF0EC70FB74A3CB1CDF6C358EA826EFF96B22C45556E7FB996779B106ED232E2D306B627DFB814&originRegion=eu-west-1&originCreation=20220116093433" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1938973621001057?token=9A527BC5108B866755BF0EC70FB74A3CB1CDF6C358EA826EFF96B22C45556E7FB996779B106ED232E2D306B627DFB814&originRegion=eu-west-1&originCreation=20220116093433</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tcam.2021.100615" target="_blank" >10.1016/j.tcam.2021.100615</a>
Alternative languages
Result language
angličtina
Original language name
Influence of fentanyl, ketamine, and lidocaine on tear production in healthy conscious dogs
Original language description
Tear production is an important factor in maintaining proper function of the cornea and conjunctiva. The purpose of this study was to determine the effects of bolus followed by infusion of fentanyl, lidocaine, and ketamine on tear production as measured by the Schirmer I Tear Test (STT-I) in dogs. A prospective, randomized, "double-blind" study was performed. A total of 55 healthy conscious client-owned dogs were included in the study. Dogs were randomly allocated to one of four groups and given intravenous fentanyl 0.005 mg kg-1 followed by 0.005 mg kg-1 hour-1 (FEN-group), ketamine 0.6 mg kg-1 followed by 0.6 mg kg-1 hour-1 (KET-group), lidocaine 1 mg kg-1 followed by 1 mg kg-1 hour-1 (LID-group), or saline 0.3 mL kg-1 followed by 2 mL kg-1 hour-1 (SAL-group). The STT-I was performed prior to (baseline) and again 30 minutes (T30) after initiation of drug administration. Data were expressed as the median (minimum maximum) and analyzed by Wilcoxon and Steel-Dwass tests (P < .05). The STT-I values increased little but were statistically sig-nificant in the KET-group from 18 (14-23) to 19 (14-25) (P = .039) and in the LID-group from 21 (14-25) to 20 (17-29) (P = .027). At 30 minutes, STT-I values were significantly higher in LID-group 20 (17-29) than in FEN-group 18 (12-22) (P = .006). Fentanyl, ketamine, and lidocaine administered at the studied doses as a bolus and then followed by an infusion within 30 minutes in healthy conscious dogs demonstrated a clinically insignificant effect on tear production as measured by STT-I.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Topics in Companion Animal Medicine
ISSN
1938-9736
e-ISSN
1946-9837
Volume of the periodical
46
Issue of the periodical within the volume
JAN-FEB
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
nestrankovano
UT code for WoS article
000740309000013
EID of the result in the Scopus database
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