Wild boar (Sus scrofa) as a possible source of Clostridioides difficile for humans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F23%3A43880948" target="_blank" >RIV/62157124:16170/23:43880948 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Wild boar (Sus scrofa) as a possible source of Clostridioides difficile for humans
Original language description
Clostridioides difficile (C. difficile) is one of the most important causative agents of life-threatening infections of the human colon, and until recently clostridial colitis was considered as a disease of mainly nosocomial origin. However, there has been an unusually high increase in the number of community infections in recent years. The aim of our work was to verify whether the wild boars really represent a possible risk for human colonization by toxin producing strains of C. difficile. We obtained 21 C. difficile isolates from 376 diaphragm muscle samples (5%), in thirteen (62%) of them was confirmed presence of genes encoding toxin production. Most of the toxinogenic isolates (10/13) carried the tcdA and tcdB genes, only three isolates had the cdtA/cdtB genes for the binary toxin identified. The detection of toxinogenic clostridia in wild boars may represent a risk of alimentary infection for humans in case of consumption of insufficiently heat-treated boar meat. The important finding is that none of our isolates showed resistance to the antibiotics of choice in the treatment of human pseudomembranous colitis caused by toxinogenic strains of C. difficile, which are metronidazole and vancomycin.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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