Acute Kidney Injury in Horses as a Consequence of Treatment with Suxibuzone.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F24%3A43881466" target="_blank" >RIV/62157124:16170/24:43881466 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.2754/avb202493020135" target="_blank" >https://doi.org/10.2754/avb202493020135</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb202493020135" target="_blank" >10.2754/avb202493020135</a>
Alternative languages
Result language
angličtina
Original language name
Acute Kidney Injury in Horses as a Consequence of Treatment with Suxibuzone.
Original language description
Suxibuzone is a prodrug of the nonsteroidal anti-inflammatory drug phenylbutazone. The aim of this study was to investigate the nephrotoxicity of suxibuzone using the recommended dosage in euhydrated horses. Serum creatinine levels were used to monitor for the presenceof acute kidney injury (AKI) in 11 systemically healthy horses treated orally with suxibuzone at the recommended dosage for five days. Symmetric dimethylarginine (SDMA), urine gamma glutamyl transferase/urine creatinine, fractional excretion of sodium, urine protein-to-creatinine ratio, and urine sediment were assessed as additional monitoring parameters. A significant increase in creatinine was found in treated horses (P = 0.002), 27% (3/11) of treated horses were classified as having AKI compared to 0% of controls (0/10), and a strong correlation was found between the change in creatinine and the change in SDMA in treated horses (τ = 0.645,P = 0.012). The results of this study suggest that treatment with suxibuzone at the recommended dosage can induce AKI even in systemically healthy euhydrated horses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta veterinaria Brno
ISSN
0001-7213
e-ISSN
1801-7576
Volume of the periodical
93
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
135-140
UT code for WoS article
001262617300003
EID of the result in the Scopus database
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