Unraveling genome- and immunome-wide genetic diversity in modern and historical Jaguars

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F25%3A43882786" target="_blank" >RIV/62157124:16170/25:43882786 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16810/25:43882786

Result on the web

<a href="https://link.springer.com/article/10.1186/s13059-025-03868-0" target="_blank" >https://link.springer.com/article/10.1186/s13059-025-03868-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13059-025-03868-0" target="_blank" >10.1186/s13059-025-03868-0</a>

Result language

angličtina

Original language name

Unraveling genome- and immunome-wide genetic diversity in modern and historical Jaguars

Original language description

BackgroundThe jaguar (Panthera onca) is a keystone species within diverse ecosystems ranging from dense rainforests to open grasslands across Central and South America. However, its populations are declining rapidly due to anthropogenic actions, such as deforestation and poaching. Here we investigate the effects of this decline on genetic diversity and genetic health. Utilizing both modern and historical museum samples, we infer population structure and immunome variability in 25 jaguars to identify unique genetic diversity that can inform targeted conservation efforts.ResultsOur genome-wide analyses identifies three distinct geographic populations: Central America, South American lowlands, and South American highlands. Modern samples that exhibit lower levels of heterozygosity also show higher levels of inbreeding. The South American lowland population shows the lowest levels of inbreeding, while the highland population exhibits the lowest overall immunome-wide variability. However, the innate (Natural Killer Cell Complex, Toll-Like Receptor) and adaptive (Major Histocompatibility Complex Class II) immune genes, which are crucial for adaptive responses and disease resilience, show high diversity in terms of heterozygosity and haplotype diversity in individuals of all three populations.ConclusionsSouth American highland and Central American jaguars face significant threats from habitat loss and fragmentation. The observed genome- and immunome-wide diversity in historical and modern jaguars reflect their recent demographic decline and challenges of local adaptation. We recommend re-evaluating evolutionarily significant units to prioritize conservation strategies, ensuring the preservation of unique genetic and adaptive diversity crucial for the species&apos; resilience and long-term survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genome Biology

ISSN

1474-760X

e-ISSN

1474-760X

Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

22

Pages from-to

nestránkováno

UT code for WoS article

001633616900003

EID of the result in the Scopus database

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