Tularemia induces different biochemical responses in BALB/c mice and common voles.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F09%3A00002244" target="_blank" >RIV/62157124:16270/09:00002244 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/09:00002141

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tularemia induces different biochemical responses in BALB/c mice and common voles.

Original language description

Background: Both BALB/c mice and common voles (Microtus arvalis) are considered highly susceptible to tularemia. However, the common vole is reported to harbour Francisella tularensis in European habitats as well as to survive longer with chronic shedding of the bacterium. The purpose of the present study was to compare the response of these two rodents to a wild Francisella tularensis subsp. holarctica strain infection. Methods: Rodents were evaluated for differences in the total antioxidant capacity derived from low-molecular-weight antioxidants, biochemistry including lipid metabolism, tissue bacterial burdens and histopathology following experimental intraperitoneal infection with 160 colony forming units (CFU) pro toto. Results: Bacterial burdensin common voles started to develop later post-exposure and amounted to lower levels than in BALB/c mice. Elevation of liver function enzymes was more pronounced in mice than common voles and there were marked differences in lipid metaboli

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

<a href="/en/project/OVUOFVZ200901" target="_blank" >OVUOFVZ200901: Classification of biological agents ? support of an international project ?Establishment and management of a common database of B-agents ? A European Laboratory Biodefence Network</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Infectious Diseases

ISSN

1471-2334

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000268568900002

EID of the result in the Scopus database

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