Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870599" target="_blank" >RIV/62157124:16270/11:43870599 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002467
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
Original language description
Objective: The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats. Background: Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE). Treatment is typically based on application of atropine and oxime reactivator. Atropine is able to protect overstimulation of muscarinic acetylcholine receptors. Application of oxime reactivator enable return of AChE activity and full suppression of intoxication. Methods: In a total, fifteen biochemical markers were assayed in plasma or blood of intoxicated animals. 42 rats were divided into 7 groups each 6 individuals. The first group was exposed to atropine; thesecond group was exposed to one LD(50) of soman and atropine. The groups 3 - 5 were exposed in a same way as the second group and were treated with oxime reactivators: HI-6 (group 3), trimedoxime (4) and K203 (5). The sixth group was con
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislava Medical Journal-Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
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Volume of the periodical
112
Issue of the periodical within the volume
10
Country of publishing house
SK - SLOVAKIA
Number of pages
6
Pages from-to
539-544
UT code for WoS article
000294514400001
EID of the result in the Scopus database
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