TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871431" target="_blank" >RIV/62157124:16270/12:43871431 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/12:43871554

Result on the web

<a href="http://dx.doi.org/10.1016/j.neuroscience.2012.06.028" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2012.06.028</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuroscience.2012.06.028" target="_blank" >10.1016/j.neuroscience.2012.06.028</a>

Result language

angličtina

Original language name

TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro

Original language description

Dementia, especially Alzheimer's disease, is a rapidly increasing medical condition that presents with enormous challenge for treatment. It is characterized by impairment in memory and cognitive function often accompanied by changes in synaptic transmission and plasticity in relevant brain regions such as the hippocampus. We recently synthesized TH-9, a conjugate racetam-methylxanthine compound and tested if it had potential for enhancing synaptic function and possibly, plasticity, by examining its effect on hippocampal fast excitatory synaptic transmission and plasticity. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 hippocampal area of na?ve juvenile male Sprague-Dawley rats using conventional electrophysiological recording techniques. TH-9 caused a concentrationdependent, long-lasting enhancement in fEPSPs. This effect was blocked by adenosine A1, acetylcholine (muscarinic and nicotinic) and glutamate (N-methyl-D-aspartate) receptor antagonists but not b

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience

ISSN

0306-4522

e-ISSN

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Volume of the periodical

220

Issue of the periodical within the volume

September

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

70-84

UT code for WoS article

000307802100009

EID of the result in the Scopus database

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