Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871458" target="_blank" >RIV/62157124:16270/12:43871458 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/12:43874620
Result on the web
<a href="http://dx.doi.org/10.3109/15376516.2011.635320" target="_blank" >http://dx.doi.org/10.3109/15376516.2011.635320</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/15376516.2011.635320" target="_blank" >10.3109/15376516.2011.635320</a>
Alternative languages
Result language
angličtina
Original language name
Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model
Original language description
Huperzine is a secondary metabolite in lycopods Huprzia and an inhibitor of acetylcholinesterase and antagonist of N-methyl-D-apartate receptor. Huperine is a suitable drug for the treatment of Alzheimer's disease as it is a part of traditional Chinese medicine. Currently, it undergoes clinical trials in the European Union and United States. The toxicological data about huperzine are missing and link between huperzine and oxidative stress has not been extensively investigated. For the above mentioned reasons, we organized experiment on a guinea pig model aimed at the investigation of adverse effects caused by huperzine. Guinea pigs were exposed to (-)-huperzine A in doses 5-625 mu g/kg. Animals were sacrificed one day after exposure. Ferric reducing antioxidant power, thiobarbituric acid reactive substances, glutathione reductase, caspase 3 activity and selected biochemical markers (e. g. transaminases, blood urea nitrogen and glucose) were assayed. In frontal, parietal, temporal lobes
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUVZU2008002" target="_blank" >OVUVZU2008002: FEVER - Method of viral hemorrhagic fevers' causative agents rapid detection and identification</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
231-235
UT code for WoS article
000300254700009
EID of the result in the Scopus database
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