Establishment of Myotis myotis cell lines - model for investigation of host-pathogen interaction in a natural host for emerging viruses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872889" target="_blank" >RIV/62157124:16270/14:43872889 - isvavai.cz</a>
Alternative codes found
RIV/68081766:_____/14:00432712 RIV/00216224:14310/14:00100366
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0109795" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0109795</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0109795" target="_blank" >10.1371/journal.pone.0109795</a>
Alternative languages
Result language
angličtina
Original language name
Establishment of Myotis myotis cell lines - model for investigation of host-pathogen interaction in a natural host for emerging viruses
Original language description
Bats are found to be the natural reservoirs for many emerging viruses. In most cases, severe clinical signs caused by such virus infections are normally not seen in bats. This indicates differences in the virus-host interactions and underlines the necessity to develop natural host related models to study these phenomena. Due to the strict protection of European bat species, immortalized cell lines are the only alternative to investigate the innate anti-virus immune mechanisms. Here, we report about theestablishment and functional characterization of Myotis myotis derived cell lines from different tissues: brain (MmBr), tonsil (MmTo), peritoneal cavity (MmPca), nasal epithelium (MmNep) and nervus olfactorius (MmNol) after immortalization by SV 40 largeT antigen. The usefulness of these cell lines to study antiviral responses has been confirmed by analysis of their susceptibility to lyssavirus infection and the mRNA patterns of immune-relevant genes after poly I:C stimulation. Performe
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"nestrankovano"
UT code for WoS article
000345204000096
EID of the result in the Scopus database
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