Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F15%3A43873952" target="_blank" >RIV/62157124:16270/15:43873952 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/15:43908493

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Degradation rate of praziquantel and fenbendazole in rainbow trout following oral administration

Original language description

The aim of this study was to evaluate and compare the rate of degradation and elimination of praziquantel and fenbendazole antiparasitics following oral administration to salmonids. In addition, we determine whether the length of the legal withholding period is sufficient for complete elimination of antiparasitic residue from the body. The use of these drugs in fish is currently considered off-label and data on degradation are not available for rainbow trout. The model species for this experiment was the rainbow trout (Oncorhynchus mykiss) and praziquantel and fenbendazole were chosen for experimental therapy. Both drugs were administered into the gastrointestinal tract using a stomach tube. Concentrations of fenbendazole and praziquantel were established through high performance liquid chromatography-tandem mass spectrometry. Our results show that concentrations of praziquantel and fenbendazole reach their maximum in the body within 24 hours of administration, with concentrations drop

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GL - Fishery

OECD FORD branch

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Project

<a href="/en/project/QJ1210013" target="_blank" >QJ1210013: Technology of the freshwater fish breeding with using of re-circulatory systems of Danish type focused on the methods of effective treatment of environment and veterinary care</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

Suppl.1

Country of publishing house

LU - LUXEMBOURG

Number of pages

4

Pages from-to

64-67

UT code for WoS article

000369404400009

EID of the result in the Scopus database

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