Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F15%3A43873962" target="_blank" >RIV/62157124:16270/15:43873962 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.etap.2015.07.009" target="_blank" >http://dx.doi.org/10.1016/j.etap.2015.07.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2015.07.009" target="_blank" >10.1016/j.etap.2015.07.009</a>

Result language

angličtina

Original language name

Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio)

Original language description

The aim of this study was to investigate the effects of naproxen on gene expression of antioxidant enzymes of adult zebrafish. Surprisingly, after two weeks exposure no significant effect on mRNA expression of the target genes was found in liver. However, mRNA levels of three genes were altered significantly in intestine. Expression of Ucp-2 decreased at the environmental concentration of 1 ?g/L while mRNA expression of GST p2 increased at the concentration of 100 ?g/L. The mRNA level for antioxidant enzyme CAT was up-regulated significantly at both concentrations used. Exposure to naproxen caused only moderate effects on expression of antioxidant genes rather in intestine than in liver, which demonstrates that intestine is more sensitive to waterbornenaproxen exposure than liver. Interestingly, adverse side effects of NSAIDs occur in the gastrointestinal tract of humans. To our knowledge, this is the first study focused on transcriptional effects of naproxen on zebrafish.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental toxicology and pharmacology

ISSN

1382-6689

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

343-348

UT code for WoS article

000362619100001

EID of the result in the Scopus database

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