Analysis of pH dose-dependent growth of sulfate-reducing bacteria

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F19%3A43877676" target="_blank" >RIV/62157124:16270/19:43877676 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00109053
Result on the web
<a href="https://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019-0010/med-2019-0010.xml" target="_blank" >https://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019-0010/med-2019-0010.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/med-2019-0010" target="_blank" >10.1515/med-2019-0010</a>

Result language
angličtina
Original language name
Analysis of pH dose-dependent growth of sulfate-reducing bacteria
Original language description
Lower intraluminal colonic pH is an indication for the development of inflammatory bowel disease including active ulcerative colitis. Involvement of intestinal sulfate-reducing bacteria in decreasing bowel pH by the production of H2S and acetate as well as their sensitivity has never been reported before. The study of the relative pH and survival of Desulfovibrio piger Vib-7 by monitoring sulfate reduction parameters was the aim of this work. Monitoring was done through the measurement of bacterial growth (biomass), dissimilatory sulfate reduction parameters: sulfate consumption, lactate oxidation, hydrogen sulfide and acetate production. According to our results, we observed that lower pH (<5) significantly inhibited D. piger Vib-7 growth. This inhibition was also noticed when alkaline media (>9 pH) was used, though the reduction was not at the rate as in media with pH of 4. The research indicates that the growth of D. piger Vib-7 is inhibited at pH of 4 which is not as low as the pH found in people with severely developed inflammatory bowel diseases such as ulcerative colitis. Certainly the interaction (synergistic effect) between both hydrogen sulfide and acetate accumulation can also play an important etiological role in the development of bowel inflammation in humans and animals.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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