Highly variable vancomycin-resistant enterococci in the north-eastern part of the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F19%3A43877923" target="_blank" >RIV/62157124:16270/19:43877923 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/19:73599762 RIV/62157124:16810/19:43877923

Result on the web

<a href="https://sfamjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/lam.13121" target="_blank" >https://sfamjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/lam.13121</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/lam.13121" target="_blank" >10.1111/lam.13121</a>

Result language

angličtina

Original language name

Highly variable vancomycin-resistant enterococci in the north-eastern part of the Czech Republic

Original language description

Vancomycin-resistant enterococci (VRE) are nosocomial pathogens of increasing medical importance. This study involved 121 VRE selectively obtained from a representative set of 1464 samples collected from various sources in the north-eastern part of the Czech Republic. In total, 119 VRE belonged to Enterococcus faecium and two to Enterococcus faecalis. All isolates of E. faecium were resistant to at least three antibiotic classes. The resistance genes vanA, erm(B), tet(M), tet(L), aac(3)-IIIa and aac(6 &apos;)-aph(2 &apos;&apos;) were detected. We assigned the E. faecium to sequence types ST5, ST18, ST38, ST64, ST92, ST273, ST549 and ST640. In E. faecium isolates, we identified the presence of replicases rep20(pLG1), rep2(pRE25), rep17(pRUM), rep21(pVEF1/2) and rep14(pRI1), as well as relaxases rel(pEF1), rel(pLG1), rel(pCIZ2), rel(pRE25) and rel(pRUM). The presence of the toxin-antitoxin system axe-txe was detected mainly among isolates of hospital origin. The A and D types of transposon Tn1546 were those occurring most frequently. Significance and Impact of the Study This is the first extensive study of vancomycin-resistant enterococci of diverse origin in a single well-defined area of the Czech Republic. The isolates were investigated for their antibiotic resistance, epidemiological characteristics and plasmid characteristics. Based on the results obtained, we can make assumptions as to the ways that vancomycin resistance is disseminated throughout the environment including humans and animals.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Applied Microbiology

ISSN

0266-8254

e-ISSN

—

Volume of the periodical

69

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

16-22

UT code for WoS article

000471301500003

EID of the result in the Scopus database

2-s2.0-85067239663