Study of the effect of paracetamol binded in polymeric nanoparticles on Daphnia magna

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F20%3A43879300" target="_blank" >RIV/62157124:16270/20:43879300 - isvavai.cz</a>
Result on the web
<a href="https://www.confer.cz/proceedings/nanocon/2020.pdf" target="_blank" >https://www.confer.cz/proceedings/nanocon/2020.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2020.3747" target="_blank" >10.37904/nanocon.2020.3747</a>

Result language
angličtina
Original language name
Study of the effect of paracetamol binded in polymeric nanoparticles on Daphnia magna
Original language description
Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 degrees C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 mu g/mL GAE and by ABTS method ranged between 40-103 mu g/mL GAE. PAR values were between 9-40 mu M. Subsequently, the biological activity of the prepared nanoparticles was tested.
Czech name
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Czech description
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Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
12TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION
ISBN
978-80-87294-98-7
ISSN
2694-930X
e-ISSN
—
Number of pages
6
Pages from-to
318-323
Publisher name
TANGER LTD KELTICKOVA 62,
Place of publication
Ostrava
Event location
Brno
Event date
Oct 21, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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