Embryotoxicity of Selective Serotonin Reuptake Inhibitors-Comparative Sensitivity of Zebrafish (Danio rerio) and African Clawed Frog (Xenopus laevis) Embryos

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F21%3A43879417" target="_blank" >RIV/62157124:16270/21:43879417 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2076-3417/11/21/10015" target="_blank" >https://www.mdpi.com/2076-3417/11/21/10015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app112110015" target="_blank" >10.3390/app112110015</a>

Result language

angličtina

Original language name

Embryotoxicity of Selective Serotonin Reuptake Inhibitors-Comparative Sensitivity of Zebrafish (Danio rerio) and African Clawed Frog (Xenopus laevis) Embryos

Original language description

Over the past twenty years, the prescription of antidepressant drugs has increased all over the world. After their application, antidepressants, like other pharmaceuticals, are excreted and enter the aquatic environment. They are dispersed among surface waters mainly through waste water sources, typically at very low concentrations- from a tenth up to hundreds of ng/L. Frequently detected antidepressants include fluoxetine and citalopram-both selective serotonin reuptake inhibitors. The aim of our study was to assess the embryotoxicity of fluoxetine hydrochloride and citalopram hydrochloride on the early life stages of zebrafish (Danio rerio) and the African clawed frog (Xenopus laevis). The embryos were exposed to various concentrations of the individual antidepressants and of their mixtures for 96 h. The tested levels included both environmentally relevant and higher concentrations for the evaluation of dose-dependent effects. Our study demonstrated that even environmentally relevant concentrations of these psychiatric drugs influenced zebrafish embryos, which was proven by a significant increase (p &lt; 0.01) in the embryos&apos; heart rates after fluoxetine hydrochloride exposure and in their hatching rate after exposure to a combination of both antidepressants, and thus revealed a potential risk to aquatic life. Despite these results, we can conclude that the African clawed frog is more sensitive, since exposure to the highest concentrations of fluoxetine hydrochloride (10,000 mu g/L) and citalopram hydrochloride (100,000 mu g/L) resulted in total mortality of the frog embryos.&lt;/p&gt;

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Sciences-Basel

ISSN

2076-3417

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

21

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

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UT code for WoS article

000718578000001

EID of the result in the Scopus database

2-s2.0-85118130367