Appraisal of a synthetic preservative, Quaternium-15, effect on three model organisms: new insight on environmental risks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F24%3A43881741" target="_blank" >RIV/62157124:16270/24:43881741 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.aquatox.2024.107138" target="_blank" >https://doi.org/10.1016/j.aquatox.2024.107138</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aquatox.2024.107138" target="_blank" >10.1016/j.aquatox.2024.107138</a>
Alternative languages
Result language
angličtina
Original language name
Appraisal of a synthetic preservative, Quaternium-15, effect on three model organisms: new insight on environmental risks
Original language description
After the COVID-19 pandemic, the use of quaternary ammonium compounds increased exponentially due to their efficacy as antimicrobials, stabilizers and disinfectants. Among these, Quaternium-15 is a preservative used in the formulation of a variety of personal care products. The increased use of this substance and the resulting persistence in wastewater treatment systems, which are unable to completely remove the Quaternium-15 from the water, is of increasing environmental concern. Using embryotoxicity analyses, this study aimed to investigate the effects of exposure to Quaternium-15 on non-target species and the resulting risks to the environment. Embryotoxicity endpoints such as mortality, hatching, presence of malformations, altered heartbeat and animal length were used to assess the effects on three model organisms (Cyprinus carpio, Danio rerio, Xenopus laevis) were evaluated during a 96-hour exposure to six different concentrations of Quaternium-15 (1, 5, 10, 15, 20 and 25 mg/L). The results obtained from the analyses highlighted: significant mortality for all three model organisms in the highest concentrations tested in which all the embryos died after 96 hpf, a delay in hatching of C. carpio and D. rerio compared to the control group, the insurgence of malformations in all the model organisms chosen and a significant decrease in heartbeat rate for the fish models. Each of these observations underlies the negative interaction between the Quaternium-15 and aquatic organisms making necessary further investigation to prevent damage to ecosystems and non-target species.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aquatic toxicology
ISSN
0166-445X
e-ISSN
1879-1514
Volume of the periodical
277
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
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UT code for WoS article
001349834700001
EID of the result in the Scopus database
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