Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F25%3A43882851" target="_blank" >RIV/62157124:16270/25:43882851 - isvavai.cz</a>

Result on the web

<a href="https://vetmed.agriculturejournals.cz/artkey/vet-202501-0004_biochemical-and-antioxidant-responses-of-common-carp-cyprinus-carpio-exposed-to-sublethal-concentrations-of-t.php" target="_blank" >https://vetmed.agriculturejournals.cz/artkey/vet-202501-0004_biochemical-and-antioxidant-responses-of-common-carp-cyprinus-carpio-exposed-to-sublethal-concentrations-of-t.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/75/2024-VETMED" target="_blank" >10.17221/75/2024-VETMED</a>

Result language

angličtina

Original language name

Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin

Original language description

The present study aimed to evaluate the biochemical and antioxidant responses of common carp after exposure to the antiepileptic and analgesic drug gabapentin at concentrations of 0.1, 1, 10, and 100 mu g/l for 4 weeks. The exposure to the highest two concentrations resulted in significant changes in plasma indices such as glucose (only group 100 mu g/l), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), lipase, creatine kinase (CK), amylase as well as butyrylcholinesterase (BChE). Similar trends were found in both groups exposed to the environmentally relevant concentrations (i.e., 0.1 and 1 mu g/l). In addition, a significant increase in the ferric-reducing power of the plasma was noted in all treated groups. Numerous changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, as well as lipid peroxidation, were observed especially in the caudal kidney in the group exposed to 100 mu g/l. Significant findings were also confirmed in the group exposed to an environmentally relevant concentration (1 mu g/l), with a decrease in superoxide dismutase in the gill and an increased lipoperoxidation in the caudal kidney. Our research shows that subchronic exposure to gabapentin may pose a significant risk to non-target aquatic organisms, such as disruption of metabolic pathways or induction of oxidative stress, even at environmentally relevant concentrations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinární medicína

ISSN

0375-8427

e-ISSN

1805-9392

Volume of the periodical

70

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

20-29

UT code for WoS article

001404108400003

EID of the result in the Scopus database

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