Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F02%3A00000626" target="_blank" >RIV/62157124:16370/02:00000626 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/02:00000003

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells

Original language description

Enhancing the pharmacological activity of all-trans retinoic acid (ATRA) is potentially useful in the management of acute promyelocytic leukemia (APL) and other types of myeloid leukemia. In this report, we identify a novel class of experimental agents selectively potentiating the cyto-differentiating activity of ATRA and synthetic RARa agonist in APL and other myelod leukemia cell lines. These agents have a bis-indolic structure and ST1346 is the prototypical compound of the series. Gene-profiling experiments and determination of the level of expression of myeloid associated markers indicate that ST1346 stimulates many aspects of the granulocytic maturation process set in motion by ATRA. Stimulation of the cyto-differentiating activity of ATRA by ST1346 enhances the efficacy of the retinoid in vivo, as demonstrated in the APL model of the SCID mouse transplanted with NB4 cells. Although the molecular mechanisms underlying the ATRA-potentiating action of ST1346 and congeners have not b

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

0006-4971

e-ISSN

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Volume of the periodical

100

Issue of the periodical within the volume

10

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

3719-3730

UT code for WoS article

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EID of the result in the Scopus database

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