Observation of changes in heart rate after newly developed ultrashort acting beta-adrenergic blockers were applied

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F02%3A00000657" target="_blank" >RIV/62157124:16370/02:00000657 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Observation of changes in heart rate after newly developed ultrashort acting beta-adrenergic blockers were applied

Original language description

The influence of the newly developed ultrashort acting beta-adrenergic blockers on the heart rate was measured on laboratory male Wistar rats with normal blood pressure. Three tested compounds were injected intravenously under general anaesthesia into the animals. At specific time intervals, the heart rate in all animals was measured from a record of their ECG. These results were converted into the percentages of perturbations of the heart rate. All evaluated compounds have shown a significant verifiable short-term bradycardic effect on the heart rate. The most significant reduction was observed in the first few minutes after i.v. administration.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavske Lekarske Listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

103

Issue of the periodical within the volume

9

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

303-304

UT code for WoS article

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EID of the result in the Scopus database

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