Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F08%3A00002550" target="_blank" >RIV/62157124:16370/08:00002550 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu

Original language description

S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately itseems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the mostdangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

Suppl.1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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