Electrochemical investigation of strontium - metallothionein interactions - analysis of serum and urine of patients with osteoporosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F09%3A00002085" target="_blank" >RIV/62157124:16370/09:00002085 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/09:5147 RIV/00216208:11130/09:5147 RIV/00023001:_____/09:00002757

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrochemical investigation of strontium - metallothionein interactions - analysis of serum and urine of patients with osteoporosis

Original language description

The main aim of this paper is to study interaction between strontium and metallothionein (MT), and to determine changes in strontium and thiols (MT, reduced glutathione, cysteine, and homocysteine) level in plasma, serum, and urine samples of patients treated with strontium ranelate (SrR). To investigate the interactions between MT and strontium(II) ions, adsorptive transfer stripping technique coupled with differential pulse voltammetry (DPV) the Brdicka reaction was employed. Besides standard Brdickasignals (Co, RS 2Co, Cat1, Cat2, Cat3), we observed new signal related to Sr-MT interaction. Further we investigated the effect of various time of interaction, concentration of strontium(II) ions and temperature of supporting electrolyte on Brdicka signals. Optimal time of interaction was 240 s. Under temperature of supporting electrolyte 20 °C, we measured linear dependence of Cat3 signal height on strontium(II) ions concentration. After that we have investigated the possibility of stro

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/IAA401990701" target="_blank" >IAA401990701: Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electroanalysis

ISSN

1040-0397

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

3-5

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

000264063500059

EID of the result in the Scopus database

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