Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870761" target="_blank" >RIV/62157124:16370/11:43870761 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid

Original language description

In a solution containing 0.067% methylparaben, 0.033% propylparaben, 3.4% glycerol and 2.0% boric acid, concentrations of both parabens, 4-hydroxybenzoic acid and 2,3-dihydroxypropyl 4-hydroxybenzoate were monitored for up to 68 months storage. 4-hydroxybenzoic acid is the main hydrolysis product of parabens, while 2,3-dihydroxypropyl 4-hydroxybenzoate was proposed as the main product of transesterification of parabens with glycerol. Results of an HPLC evaluation of parabens, 4-hydroxybenzoic acid and 2,3- dihydroxypropyl 4-hydroxybenzoate showed that the decomposition of 68 months old samples stored at room temperature did not exceed 2.0%. The stability of both parabens in a medicinal preparation of the stated composition has thus been satisfactorilydemonstrated after more than 5 years of storage under ambient conditions. The transesterification reaction was shown to influence the chemical stability of parabens to an extent comparable to hydrolysis. Moreover, the presence of 2,3-dihy

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Excipients and Food Chemicals

ISSN

2150-2668

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

41-49

UT code for WoS article

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EID of the result in the Scopus database

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