Relationship between chemical structure, binding affinity and selectivity towards alfa1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870898" target="_blank" >RIV/62157124:16370/11:43870898 - isvavai.cz</a>

Result on the web

<a href="http://versita.metapress.com/content/l465316n7362w6l0/fulltext.pdf" target="_blank" >http://versita.metapress.com/content/l465316n7362w6l0/fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10219-011-0005-1" target="_blank" >10.2478/v10219-011-0005-1</a>

Result language

angličtina

Original language name

Relationship between chemical structure, binding affinity and selectivity towards alfa1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain

Original language description

The N-phenylpiperazine structures exhibit very extensive multiple receptor activities including the influencing of alfa1-adrenoceptors (alfa1-AR). Their antagonistic activity towards alfa1-AR is intensively applied in the therapy of cardiovascular systemdiseases - e. g. hypertension as well as in the treatment of benign prostatic hyperplasia. The limited ratio of selective effect on the specific subtypes of the alfa1-AR by certain drugs used in the practice (azosine-type structures) leads to multiple side effects which includes postural hypotension, syncope or first dose phenomena. The existence of multiple alfa1-AR subtypes holds promise for the discovery, projection and development of more specific selective drug molecules targeting only one alfa1-adrenoceptor subtype and making them free from side effects. Towards this aim wide-ranging modifications have been reported in the literature on the "basic" structure of the N-phenylpiperazine-based molecules. The present paper deals with

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava

ISSN

0301-2298

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

14

Pages from-to

42-55

UT code for WoS article

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EID of the result in the Scopus database

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