Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871259" target="_blank" >RIV/62157124:16370/12:43871259 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejpb.2012.02.011" target="_blank" >http://dx.doi.org/10.1016/j.ejpb.2012.02.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejpb.2012.02.011" target="_blank" >10.1016/j.ejpb.2012.02.011</a>

Result language
angličtina
Original language name
Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis
Original language description
Topical delivery of 5-aminosalicylic acid (5-ASA) to the colonic mucosa is important in order to achieve effective drug concentration in the site of inflammation and to minimize its systemic availability. 5-ASA loaded pellets were prepared by an extrusion/spheronization method. Mucoadhesive biopolymer chitosan was incorporated into the pellets, and drug delivery to the colon was controlled by the pH-sensitive polymer Eudragit (R) FS. Dissolution profiles of coated pellets revealed no drug release at pH1.2 within 2 h and release as intended in the simulated distal ileum and colon. In vivo, chitosan-core drug loaded pellets (AMCh) showed 2.5-fold higher drug metabolite concentration than after chitosan free pellets (AM) administration in the inflamed colonic tissue. Additionally, AMCh demonstrated decreased in AUC in colitis group (1507 +/- 400 ng h/ml) compared with AM (1907 +/- 122 ng h/ml). In terms of therapeutic efficiency, administration of pellets markedly decreased the colon/bod
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NS10222" target="_blank" >NS10222: Microparticle dosage form for theraphy of nonspecific inflammatory bowel diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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