Gene Polymorphisms Involved in Manifestation of Leucopenia, Digestive Intolerance, and Pancreatitis in Azathioprine-Treated Patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871450" target="_blank" >RIV/62157124:16370/12:43871450 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10620-012-2163-y" target="_blank" >http://dx.doi.org/10.1007/s10620-012-2163-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10620-012-2163-y" target="_blank" >10.1007/s10620-012-2163-y</a>

Result language
angličtina
Original language name
Gene Polymorphisms Involved in Manifestation of Leucopenia, Digestive Intolerance, and Pancreatitis in Azathioprine-Treated Patients
Original language description
Approximately 10-28 % of patients experience adverse drug reactions related to treatment with thiopurines. The most serious reaction is myelosuppression, typically manifested as leucopenia, which occurs in approximately 2-5 % of patients. Other adverse drug reactions that often accompany thiopurine therapy are pancreatitis, hepatotoxicity, allergic reactions, digestive intolerance, arthralgia, febrile conditions, and rash. The objective of this study was to assess the relationship between variant alleles of thiopurine S-methyltransferase (SNPs 238G } C, 460G } A and 719A } G), inosine triphosphate diphosphatase (SNPs 94C } A and IVS2 + 21A } C), and xanthine dehydrogenase (837C } T) and the occurrence of adverse drug reactions to azathioprine therapy.Genotype was determined for 188 Caucasians diagnosed with inflammatory bowel disease treated with a standard dose of azathioprine (1.4-2.0 mg/kg/day). Variant genotype thiopurine S-methyltransferase predisposes to development of leucopeni
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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