Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871550" target="_blank" >RIV/62157124:16370/12:43871550 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/50626" target="_blank" >http://dx.doi.org/10.5772/50626</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/50626" target="_blank" >10.5772/50626</a>
Alternative languages
Result language
angličtina
Original language name
Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers
Original language description
Twenty-eight carbohydrate derivatives were evaluated as formers during crystallization process of monosodium salts of alendronate, ibandronate and risedronate. All prepared samples were screened by FT-NIR and FT-Raman spectroscopy, and some new entitieswere checked by 31P and 13C CP/MAS NMR spectroscopy, XRPD and DSC. In the present study the relationships between the chemical structures of bisphosphonates and carbohydrates required for crystalline form change are investigated and discussed. It can beconcluded that in general carbohydrates can be used as crystallization modifiers, although none of carbohydrates afforded a new solid phase with alendronate. Ibandronate and risedronate generated new solid phases with phenyl-beta-D-galactopyranoside. Itis worth to note that both BPs IV and V contain trisubstituted nitrogen in contrast to alendronate (III), which can be an important factor that can cause different interactions. In case of BP IV it can be speculated about co-crystal gener
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology
ISBN
978-953-51-0864-1
Number of pages of the result
36
Pages from-to
81-116
Number of pages of the book
558
Publisher name
InTech
Place of publication
Rijeka, Croatia
UT code for WoS chapter
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