Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871636" target="_blank" >RIV/62157124:16370/12:43871636 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/v10219-012-0025-5" target="_blank" >http://dx.doi.org/10.2478/v10219-012-0025-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10219-012-0025-5" target="_blank" >10.2478/v10219-012-0025-5</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis
Original language description
The aim of this work is the study of stability and kinetics of hydrolysis of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl)ethylamino]propyl-4- [(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino] propyl-4-[(alkoxycarbonyl)amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in the position of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyl- to butyl-) carbamate. Thin layer chromatography and UV-area spectrophotometry are used in order to establish the stability of these potential pharmaceuticals. The stability studies of the compounds were examined in acidic and alkaline media,in buffers and due oxidation at room and at elevated temperature chromatographically, and Rf values of incipient products and degradation products were detected. Kinetics of acid and base hydrolysis in various solutions at temperatures 80
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava
ISSN
0301-2298
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
54-62
UT code for WoS article
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EID of the result in the Scopus database
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