Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872229" target="_blank" >RIV/62157124:16370/13:43872229 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jps.23494" target="_blank" >http://dx.doi.org/10.1002/jps.23494</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jps.23494" target="_blank" >10.1002/jps.23494</a>
Alternative languages
Result language
angličtina
Original language name
Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine
Original language description
Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transittimes for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca2+ ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. (C) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical sciences
ISSN
0022-3549
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
2995-3017
UT code for WoS article
000330240900011
EID of the result in the Scopus database
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