The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873139" target="_blank" >RIV/62157124:16370/14:43873139 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1055/s-0034-1368426" target="_blank" >http://dx.doi.org/10.1055/s-0034-1368426</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0034-1368426" target="_blank" >10.1055/s-0034-1368426</a>
Alternative languages
Result language
angličtina
Original language name
The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart
Original language description
Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Planta Medica
ISSN
0032-0943
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
525-532
UT code for WoS article
000336493000001
EID of the result in the Scopus database
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