Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43872703" target="_blank" >RIV/62157124:16370/15:43872703 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2298/JSC131128032F" target="_blank" >http://dx.doi.org/10.2298/JSC131128032F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2298/JSC131128032F" target="_blank" >10.2298/JSC131128032F</a>

Result language
angličtina
Original language name
Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
Original language description
Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was performed. The dobesilates were characterized by standard spectral methods and by AAS for metal content and then tested for inhibitory activity against aminopeptidase N. Calcium and magnesium 2,5-dihydroxybenzene sulfonates exhibited rather weak inhibitory activity to aminopeptidase N as demonstrated by IC50 values of 978.0 and 832.1 umol l-1 respectively while zinc 2,5-dihydroxybenzene sulfonate reached the more significant inhibitory activity characterized by IC5077.4 umol l-1. The inhibitory activity results suggest that the inhibition of aminopeptidase N could play a role in the anti-angiogenic activity of 2,5-dihydroxybenzenesulfonates.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)