Evidence for CD34/SMA positive cells in the left main coronary artery in atherogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874488" target="_blank" >RIV/62157124:16370/16:43874488 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.acthis.2016.04.005" target="_blank" >http://dx.doi.org/10.1016/j.acthis.2016.04.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.acthis.2016.04.005" target="_blank" >10.1016/j.acthis.2016.04.005</a>

Result language

angličtina

Original language name

Evidence for CD34/SMA positive cells in the left main coronary artery in atherogenesis

Original language description

Regression of atherosclerosis is a key aspect of preventing further coronary artery disease and understanding which cell type forms smooth muscle cells in atherosclerotic fibrous caps will aid in reducing CAD. Atherogenesis is a complex interplay of cells migrating and proliferating into the vascular wall. CD34 positive hemapoetic stem cells are believed to not transform into vascular smooth muscle cells (SMC). The current study hypothesised that there would be no evidence for CD34(+)/alpha SMC actin(+) cells in atherosclerotic coronary arteries. Aims: To identify CD34(+)/alpha actin positive cells in the fibrous cap and wall of atherosclerotic plaques in the coronary artery. Methods: Male New Zealand White rabbits were fed a diet containing 0.5% cholesterol and 1% methionine for 4 weeks, then 9 weeks of normal diet to induce regression. Immunohistochemistry was used to detect CD34(+) haematopoietic progenitor cells and SMC actin. Results: In the fibrous cap, the majority of cells were CD34(-)/alpha SMC actin(+) spindle shaped cells. However very rare populations of CD34(+)/alpha SMC actin(+) and CD34(+)/alpha SMC actin(-) cells were also present but these cells were not spindle shaped. Conclusion: Our study found that CD34(+)/alpha SMC actin spindle shaped cells were absent from the fibrous cap. Moreover, the predominant cell population were the vascular smooth muscle cells (CD34(-)/alpha SMC actin(+)) but (CD34(+)/alpha SMC actin(+)) cells were also present. This model could be used to understand the role of each SMC population subtype to hasten atherosclerotic regression in the coronary artery.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACTA HISTOCHEMICA

ISSN

0065-1281

e-ISSN

—

Volume of the periodical

118

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

413-417

UT code for WoS article

000378958100012

EID of the result in the Scopus database

—