Depot risperidone-induced adverse metabolic alterations in female rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875715" target="_blank" >RIV/62157124:16370/17:43875715 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00096183

Result on the web

<a href="http://dx.doi.org/10.1177/0269881117691466" target="_blank" >http://dx.doi.org/10.1177/0269881117691466</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0269881117691466" target="_blank" >10.1177/0269881117691466</a>

Result language

angličtina

Original language name

Depot risperidone-induced adverse metabolic alterations in female rats

Original language description

Atypical antipsychotics are associated with adverse metabolic effects including weight gain, increased adiposity, dyslipidaemia, alterations in glucose metabolism and insulin resistance. Increasing evidence suggests that metabolic dysregulation precedes weight gain development. The aim of this study was to evaluate alterations in adipokines, hormones and basic serum biochemical parameters induced by chronic treatment with depot risperidone at two doses (20 and 40 mg/kg) in female Sprague-Dawley rats. Dose-dependent metabolic alterations induced by risperidone after 6 weeks of treatment were revealed. Concomitant to weight gain and increased liver weight, an adverse lipid profile with an elevated triglyceride level was observed in the high exposure group, administered a 40 mg/kg dose repeatedly, while the low dose exposure group, administered a 20 mg/kg dose, developed weight gain without alterations in the lipid profile and adipokine levels. An initial peak in leptin serum level after the higher dose was observed in the absence of weight gain. This finding may indicate that the metabolic alterations observed in this study are not consequent to body weight gain. Taken together, these data may support the primary effects of atypical antipsychotics on peripheral tissues.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of psychopharmacology

ISSN

0269-8811

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

487-499

UT code for WoS article

000400179400009

EID of the result in the Scopus database

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