Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876020" target="_blank" >RIV/62157124:16370/17:43876020 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00098632 RIV/00159816:_____/17:00067712
Result on the web
<a href="http://dx.doi.org/10.1080/01635581.2017.1263751" target="_blank" >http://dx.doi.org/10.1080/01635581.2017.1263751</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/01635581.2017.1263751" target="_blank" >10.1080/01635581.2017.1263751</a>
Alternative languages
Result language
angličtina
Original language name
Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
Original language description
The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrition and cancer-an international journal
ISSN
0163-5581
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
177-183
UT code for WoS article
000394613600001
EID of the result in the Scopus database
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