THE IN VITRO ANTIOXIDANT PROPERTIES OF 2-ALKOXYPHENYLCARBAMIC ACID DERIVATIVES CONTAINING A 4 '-(SUBSTITUTED PHENYL) PIPERAZIN- 1 '- YL MOIETY DETERMINED BY THE 2,2 '- AZINOBIS(3-ETHYLBENZOTHIAZOLINE-6-SULFONIC ACID) DERIVED RADICAL CATION (ABTS(center dot+)) AND FERRIC REDUCING ANTIOXIDANT POWER (FRAP) ASSAYS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876152" target="_blank" >RIV/62157124:16370/17:43876152 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.14499/indonesianjpharm28iss1pp1" target="_blank" >http://dx.doi.org/10.14499/indonesianjpharm28iss1pp1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14499/indonesianjpharm28iss1pp1" target="_blank" >10.14499/indonesianjpharm28iss1pp1</a>
Alternative languages
Result language
angličtina
Original language name
THE IN VITRO ANTIOXIDANT PROPERTIES OF 2-ALKOXYPHENYLCARBAMIC ACID DERIVATIVES CONTAINING A 4 '-(SUBSTITUTED PHENYL) PIPERAZIN- 1 '- YL MOIETY DETERMINED BY THE 2,2 '- AZINOBIS(3-ETHYLBENZOTHIAZOLINE-6-SULFONIC ACID) DERIVED RADICAL CATION (ABTS(center dot+)) AND FERRIC REDUCING ANTIOXIDANT POWER (FRAP) ASSAYS
Original language description
In an effort to comprehensively characterize an antioxidant profile of 2-alkoxyphenylcarbamic acid-based compounds containing a 4 '-(substituted phenyl) piperazin-1 '- yl fragment, they were in vitro screened in the 2,2 ' -azino-bis(3-ethylbenzothiazoline-6- sulfonic acid) derived radical cation (ABTS(center dot+)) and ferric reducing antioxidant power (FRAP) assay using the UV/VIS spectrophotometry. The ABTS(center dot+) scavenging (reducing) potential of 1-[3-(2-methoxyphenylcarbamoyl) oxy-2- hydroxypropyl]-4-(4-fluorophenyl) piperazin-1-ium chloride was found to be the most promising and it was comparable to the efficiency of the carvedilol reference drug. Moreover, that 4 ' - fluoro group-containing compound was regarded as more active than the atenolol standard. When testing the molecules ' power to reduce the ferric 2,4,6-tris (2-pyridyl)-s-triazine complex [Fe(III)(TPTZ) 2] (3+), the most prospective was 1-[3-(2-ethoxyphenylcarbamoyl) oxy-2- hydroxypropyl]- 4-( 4-fluorophenyl) piperazin-1-ium chloride. On the other hand, its Fe3+ reducing power was lower compared to both standards carvedilol and atenolol. The study discussed structure-antioxidant properties relationships considering electronic, steric and lipophilic features.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Indonesian journal of pharmacy
ISSN
2338-9427
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
1
Country of publishing house
ID - INDONESIA
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000411629700001
EID of the result in the Scopus database
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