DIFFERENCE IN SYSTOLIC PRESSURE VALUES AT INFLATION AND DEFLATION OF THE CUFF IN RATS WITH GOLDBLATT RENAL HYPERTENSION

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876876" target="_blank" >RIV/62157124:16370/18:43876876 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DIFFERENCE IN SYSTOLIC PRESSURE VALUES AT INFLATION AND DEFLATION OF THE CUFF IN RATS WITH GOLDBLATT RENAL HYPERTENSION
Original language description
Clinically relevant animal models should mirror basic epidemiology data from real patients ? age, sex, primary disease i.e. diabetes, hypertension... Hypertension is most frequent concomitant disease and is the cause of many cardiovascular diseases. For our needs stroke study) we use Goldblatt renal hypertension model (GRHM). Three-month-old, male, Wistar rats were divided in groups: 2K1S (n=9), 2K2S (n=5), KON (n=11). In the 2K1S left renal artery was stenotized; in the 2K2S both renal arteries and in KON group a sham surgery was performed. Four months after surgery the blood pressure was measured (tail artery, rats cuff, vascular doppler flow detection). The measurement was performed under isoflurane anesthesia. The measurement was repeated 3 times and systolic arterial pressure values in cuff inflation (SAPi) and cuffs deflation (SAPd) were recorded. SAPi values (mean ? SD) were in 2K1S group 140?29 mm Hg, in 2K2S 144?20 mm Hg and in KON group 113?13mm Hg. Differences in systolic pressure at inflation and deflation of the cuff (SAPi-SAPd) were 12?4 mm Hg in 2K1S group, 11?5 mm Hg in 2K2S group and 2?2 mm Hg in KON group. GRHM produce elevation of SAPi-SAPd compared to control group.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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