Nanofibre-based mucoadhesive film for oromucosal delivery of therapeutic nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876921" target="_blank" >RIV/62157124:16370/18:43876921 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nanofibre-based mucoadhesive film for oromucosal delivery of therapeutic nanoparticles
Original language description
The oromucosal route of administration is an alternative route for drug-delivery and vaccine delivery. This has been used successfully for local and systemic delivery of lowmolecular-weight substances with a rapid onset of pharmacological effects, and also for drugs formulated into controlled-release systems. In addition, mucosal, especially sublingual delivery of macromolecular drug and antigen-delivery nanoparticles has become an important topic of recent research as well. In general, high permeability, a lack of enzymatic barriers, mild pH values, easy access for self-administration, and opportunities to bypass first-pass metabolism, all make the non-keratinized oral regions attractive sites for the administration of drugs and vaccines. New approaches and formulations that utilize mucoadhesives, mucus penetrating particles, or absorption enhancers can enable effective transmucosal delivery of macromolecular therapeutics, antigens and nanoparticle-based delivery systems.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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