A rapid method for the sarcosine detection using pseudo-peroxidase activity of superparamagnetic iron oxide nanoparticles (SPIONS)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877005" target="_blank" >RIV/62157124:16370/18:43877005 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A rapid method for the sarcosine detection using pseudo-peroxidase activity of superparamagnetic iron oxide nanoparticles (SPIONS)

Original language description

Sarcosine is an amino acid that is formed by methylation of glycine and is present in trace amounts in the body. Increased sarcosine concentrations in blood plasma and urine are manifested in sarcosinemia and in some other diseases such as prostate cancer. For this purpose, sarcosine detection using the nanomedicine approach was proposed. In this study, we have prepared superparamagnetic iron oxide nanoparticles (SPIONs) with different modified surface area. Gold nanoparticles (AuNPs) were modified by chitosan (CS), and sarcosine oxidase (SOX). SPIONs without any modification were taken as controls. The proposed detection system allows to analyse sarcosine as a potential prostate cancer marker at micromolar concentrations and to monitor changes in its levels.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů