Adipokines in neurovascular diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877063" target="_blank" >RIV/62157124:16370/18:43877063 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00102964 RIV/00159816:_____/18:00068574
Result on the web
<a href="http://dx.doi.org/10.1016/j.biopha.2017.12.074" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.12.074</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopha.2017.12.074" target="_blank" >10.1016/j.biopha.2017.12.074</a>
Alternative languages
Result language
angličtina
Original language name
Adipokines in neurovascular diseases
Original language description
Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicine & pharmacotherapy
ISSN
0753-3322
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
February
Country of publishing house
FR - FRANCE
Number of pages
9
Pages from-to
424-432
UT code for WoS article
000426104000053
EID of the result in the Scopus database
2-s2.0-85038847621