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Adipokines in neurovascular diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877063" target="_blank" >RIV/62157124:16370/18:43877063 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/18:00102964 RIV/00159816:_____/18:00068574

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.biopha.2017.12.074" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.12.074</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.biopha.2017.12.074" target="_blank" >10.1016/j.biopha.2017.12.074</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adipokines in neurovascular diseases

  • Original language description

    Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedicine &amp; pharmacotherapy

  • ISSN

    0753-3322

  • e-ISSN

  • Volume of the periodical

    98

  • Issue of the periodical within the volume

    February

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    9

  • Pages from-to

    424-432

  • UT code for WoS article

    000426104000053

  • EID of the result in the Scopus database

    2-s2.0-85038847621