Genetic association of single nucleotide polymorphisms of FZD4 and BDNF genes with retinopathy of prematurity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877068" target="_blank" >RIV/62157124:16370/18:43877068 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/13816810.2018.1432064" target="_blank" >http://dx.doi.org/10.1080/13816810.2018.1432064</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13816810.2018.1432064" target="_blank" >10.1080/13816810.2018.1432064</a>
Alternative languages
Result language
angličtina
Original language name
Genetic association of single nucleotide polymorphisms of FZD4 and BDNF genes with retinopathy of prematurity
Original language description
Background: Retinopathy of prematurity (ROP) is a multifactorial disease occurring in preterm neonates, caused by incorrect development of retinal blood vessels. It has been suggested that, in addition to gestational age, weight, and oxygen supplementation, genetic factors can play a role in the pathogenesis of ROP. Methods: In the present prospective study, 97 neonates were enrolled based on the gestational age and weight, and genomic DNA from patients diagnosed with ROP and premature newborns without ROP was collected. The DNA sequence of protein coding and 5' and 3' untranslated regions (UTRs) of the frizzled-4 (FZD4) gene and the genotype of the locus rs7934165:G > A (NM_170731.4: c.3+10976 C > T) within the brain-derived neurotrophic factor gene (BDNF) were determined. Results: We detected a significant association between rs61749246:C > A (NM_012193.3: c.*2G > T) and ROP in a general genetic model as well as in a multiplicative model and by the Cochran-Armitage test for trend. Moreover, rs61749246 was strongly associated with ROP, requiring surgical intervention. Conclusion: We suggest that rs61749246:C > A of the FZD4 gene is likely associated with the development of ROP. It is necessary to confirm this suggestion in larger studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ophthalmic Genetics
ISSN
1381-6810
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
332-337
UT code for WoS article
000430504100007
EID of the result in the Scopus database
2-s2.0-85042218984