Antitussive activity of alcoxyphenyl carbamic acid analogues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877071" target="_blank" >RIV/62157124:16370/18:43877071 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2017048" target="_blank" >http://dx.doi.org/10.4149/gpb_2017048</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2017048" target="_blank" >10.4149/gpb_2017048</a>
Alternative languages
Result language
angličtina
Original language name
Antitussive activity of alcoxyphenyl carbamic acid analogues
Original language description
In this study we report pharmacological evaluation of four newly synthetized analogues of alcoxyphenyl carbamic acid, structurally related to butamirate citrate that is frequently used as cough suppressing drug, and marked as ATK 231, ATK 241, ATK 251 and ATK 261. These agents with various modifications of the molecular structure have been tested for antitussive activity in cough induced by inhalation of aerosol of citric acid (0.3 M) over 3 minutes using conscious guinea pigs. Results revealed significant cough suppressing activity without significant influence on specific airways resistances in all tested substances. ATK 231 and ATK241 showed significantly higher total antitussive activities when compared to both codeine phosphate and butamirate citrate, while ATK 251 only comparing to butamirate citrate. We did not observe any notable adverse effects and these compounds could thus potentially represent promising new non -narcotic antitussives suitable for further studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
General physiology and biophysics
ISSN
0231-5882
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
337-343
UT code for WoS article
000435065400010
EID of the result in the Scopus database
2-s2.0-85048512426